Medical Marijuana What on earth is Your Difference Involving CBD And THC
CBD or cannabidiol is deprived of psychoactive properties, but it will help with various diseases
Recently, the main topics medical marijuana has been surfacing more and more often in foreign media, scientists are trying their utmost to obtain permissions and funding for research of this type, believing in its promise, and in lots of countries of the entire world, decriminalization and legalization are underway.
Most hype now causes a substance such as CBD or cannabidiol included in the hemp plant. Today it are available anywhere – from food to decorative cosmetics and quite legally purchased cbd gummies for pain uk in internet vendors in the form of oil. And all because CBD does not have psychoactive properties, unlike tetrahydrocannabinol (THC), but it has healing properties.
Since CBD is an energetic component of marijuana itself, you may get profit from it by smoking a shared in the old fashioned way. The most important thing would be to be sure that a class with a predominance of this specific substance, rather than THC, is clogged in your joint in the event that you would like to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to manage paranoia.
Let’s try to work out how this magical cannabidiol works, on the basis of the latest data from the entire world of science and the ability of consumers using CBD as a medication, and not for fun.
The difference between the results of CBD and THC
Since cannabidiol is not really a psychoactive substance, you can’t get high from it, but it’s easy to increase your productivity, relieve anxiety and relieve pain. When utilizing CBD, thoughts aren’t confused, memory doesn’t deteriorate, and as a result of muscle relaxation, you do not become a vegetable, as is usually the case with smoking cannabis varieties with a predominance of THC.
If the ratio of those substances is approximately exactly the same, then you definitely will see a slight euphoric and the above-mentioned beneficial effects at exactly the same time. At the same time, such negative consequences as paranoia, dry mouth, drying out and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are often due to THC, do not occur. Such varieties are most often used as a painkiller.
Although CBD is effective alone, some experts still insist that in conjunction with other active aspects of marijuana, it brings more benefits:
“To attain a much better therapeutic effect, you will need a mix of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not yet say with accuracy. This knowledge gap is caused, to start with, by deficiencies in research data, considering that the field of studying the healing properties of hemp is still in its infancy. But the gradual legalization of medical marijuana shows that scientists will soon do have more freedom for his or her experiments. So hold the fists, hope and believe.
What diseases cannabidiol helps to cope with
Some scientific papers suggest that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope this substance may help pharmaceutical companies to produce effective drugs against many disorders and diseases followed by similar symptoms.
The list of such diseases includes, but is not limited by such pathological conditions:
To date, there are no full-fledged drugs based on CBD to combat these disorders, but many patients declare that the substance helps them to ease and even completely eliminate the symptoms.
Recently in the USA, where marijuana is still on the list of the very most dangerous psychoactive substances, there has been a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the very first marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant effect of that the FDA has confirmed using its tests. Today, Epidiolex is employed to treat severe types of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there have been other drugs on the basis of the aspects of marijuana. As an example, the Belgian company Solvay Pharmaceuticals in 1985 created Marinol (dronabinol), a medication that’s simply a manufactured THC, which can be still used today to increase the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal areas of CBD and THC, to ease muscle cramps and other symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there’s still not really much data on how CBD has a beneficial effect on the body, scientists still involve some ideas with this subject. Surprisingly, cannabidiol doesn’t bind to the active sites of the cannabinoid receptors CB1 and CB2, as does exactly the same THC. However it interacts with the GPR55 protein secreted in the brain and peripheral organs. Researchers believe this determines its antispasmodic effect.
In the brain, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted in one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more often than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, based on Ben Wally, head of research at GW Pharmaceuticals.
The partnership of this protein with CBD is confirmed by experiments with genetically modified rodents by which epileptic seizures were caused. Those animals by which GPR55 was present taken care of immediately cannabidiol treatment, and rats without protein continued to experience convulsions.
Wally also believes that CBD can contribute to the desensitization of the TRPV1 protein, which can be involved in the transport of ions and calcium within the body, which also helps relieve cramping. First, cannabidiol activates this protein, but then quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 do not react to CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance made by the body. Wally believes that cannabidiol suppresses seizures, mainly because of its effect on adenosine, but more experiments are required to verify this hypothesis.
This type of wide range of areas by which CBD is active allows scientists to suggest this substance might be useful in the treating motor disorders, such as Parkinson’s disease. And the interaction with serotonin receptors shows that cannabidiol can be used to treat depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as Roger Pertwee, a professor at the University of Aberdeen and the top of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it cannot be confidently stated that the interaction of CBD with one of these receptors and proteins means so it causes a therapeutic effect of this substance.
High CBD Marijuana Varieties
Finally, we will provide you with a set of popular cannabidiol-dominated varieties so do you know what to ask about next amount of time in your telegram supermarket: